PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling

Abstract Background PCA3 is a non-coding RNA (ncRNA) that is highly expressed in prostate cancer (PCa) cells, but its functional role is unknown.To investigate its putative function in PCa biology, we used gene expression knockdown by small interference RNA, and also analyzed its involvement in androgen receptor (AR) signaling.Methods LNCaP and PC3

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A Variable Block Insertion Heuristic for Solving Permutation Flow Shop Scheduling Problem with Makespan Criterion

In this paper, we propose a variable block insertion heuristic (VBIH) algorithm to solve the permutation flow shop scheduling problem (PFSP).The VBIH algorithm removes a block of jobs from the current solution.It applies an insertion local search to the partial solution.Then, it inserts the block into all possible positions in the partial solution

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